Las Vegas has a few areas to visit; mainly of course, the strip. Also check out Freemont Street (Old Vegas). In a sense of irony Old Vegas is now extremely modern with a massive digital canopy that covers the entire outdoor walkway nearly 2000ft long. Here you can try you luck at the 4 Queens!
Las Vegas is not known for having an LGBTQ distrcit on the strip, but they do have an area, affectionately, known as the Fruit Loop. It has a few gay bars and some friendly hotels including; The Hyatt and Holiday Royal. The most gay friendly hotels on the strip will be The Linq and The Flamingo. The Flamingo is home to the “Rupaul's Drag Race Live” and in the summers are known for hosting LGBTQ pool parties! So, it’s super friendly right now.
There are two bars that stay open 24/7 (Quadz and Free Zone) and one that only opens on weekends (Piranha Night Club). The first two have bingo and trivia nights, happy hours, themed nightly events, and great drink prices. As for Piranha they great drag shows and has a very upscale atmosphere.
The strip can be accepting to everyone, unless you are looking for trouble and don’t mind your own business. The city is beautiful at night and you will have a fabulous time, make unexpected friends, and never be alone if you decide to travel by yourself. Wink Wink ;)
McCarran International Airport (LAS). Unlike like most major airports, regulations prohibit individual hotels on the Vegas Strip from operating private shuttles to and from the airport. You can, however, take a shuttle bus to the strip for under $10/person located just outside the baggage claim areas.
There is a public bus transportation called RTC. It is better to get a Lyft/Uber/taxi, however, as outside of every hotel are designated spots for these providers.
Fun fact, it is illegal for these car share providers to pick you on the street like a normal city would allow. They absolutely must pick you up at a designated spot, so don't be pissed off and surprised if one passes you while you try to wave them down. Look for the designated spots, you'll always find one outside of a hotel.
Otherwise, there is a Monorail that takes you from hotel to hotel, but not all of them on the strip, but it is very convenient if you are able.
For the more adventurists you must check out the Stratosphere; a 107 story building with a fun adult amusement park on the roof which includes a hardness free fall leap from the top of the building to the ground level.
For more natural sites for hiking and taking in the beauty; you can check out Red Rock Canyon, Mount Charleston, Mary Jane Falls, the Hoover Dam, Death Valley, Nelson’s Landing, Lake Mead, and so much more, all an hour or two away from the strip!